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高高锦明

高锦明

Gao Jinming

西北农林科技大学化学与药学院教授
Professor, College of Chemistry and Pharmacy, Northwest A&F University
现代科学
Modern Science
“要做到物尽其用,就要从深层次做文章。”

人物简介

绘制杜仲化学成分'资源图谱',发现抗神经炎症三萜。

事迹

高锦明,西北农林科技大学化学与药学院教授,从2000年起带领团队跨界开展杜仲化学成分研究,是西农三代'杜仲军团'中承前启后的关键人物。他利用高效液相色谱等现代分析技术绘制出杜仲化学成分的'资源图谱',让杜仲叶、皮、花、籽的科学开发有了简明指南,改变了过去'只售一张皮'的粗放利用模式。

其团队从杜仲叶中首次分离出具有抗神经炎症作用的特殊降三萜成分,为杜仲叶功能食品开发和神经退行性疾病预防开辟了新方向。作为主要完成人参与的'杜仲新品种选育与次生代谢物深度开发利用'获2017年度陕西省科学技术一等奖。他的工作支撑略阳县形成涵盖胶、药、食、饲的杜仲全产业链,年产值超1.2亿元。

重要活动 / 事件

  • 2026年1-2月作为西农'杜仲军团'第三代骨干接受中国科学报、中国青年报采访
  • 长期为陕西略阳县(全国杜仲种植第一大县,60万亩)杜仲综合开发提供技术支撑
  • 参与出版杜仲次生代谢物相关专著

代表贡献

  • 2000年起用高效液相色谱等技术绘制杜仲不同部位化学成分'资源图谱',明确叶是绿原酸和黄酮宝库、皮是杜仲胶和苷类首选
  • 首次从杜仲叶中分离出具有抗神经炎症作用的降三萜成分
  • 作为'秦仲1-4号杜仲良种选育与次生代谢物深度开发利用'主要完成人获2017年度陕西省科学技术一等奖
  • 研究成果为杜仲叶功能食品和阿尔茨海默病等神经退行性疾病预防药物研发提供科学依据
“To make full use of everything, one must work at a deeper level.”

Profile

Mapped the chemical-component 'resource atlas' of Eucommia and discovered anti-neuroinflammatory nor-triterpenes.

Story

Gao Jinming is a professor at the College of Chemistry and Pharmacy, Northwest A&F University. Since 2000 he has led his team in cross-disciplinary research on the chemical components of Eucommia, serving as a key link between generations of Northwest A&F's three-generation 'Eucommia Corps'. Using modern analytical techniques such as HPLC, he mapped a 'resource atlas' of Eucommia's chemical components, giving the scientific development of Eucommia leaves, bark, flowers and seeds a concise guide and changing the past crude utilization model of 'selling only the bark'.

His team was the first to isolate special nor-triterpene constituents with anti-neuroinflammatory activity from Eucommia leaves, opening a new direction for Eucommia-leaf functional foods and the prevention of neurodegenerative diseases. As a major completer of 'Breeding of new Eucommia varieties and in-depth development and utilization of secondary metabolites', he won the 2017 Shaanxi Provincial Science and Technology Award (First Prize). His work has supported Lueyang County in forming a Eucommia whole industry chain spanning rubber, medicine, food and feed, with an annual output value exceeding 120 million yuan.

Milestones

  • In January-February 2026, interviewed by China Science Daily and China Youth Daily as a third-generation backbone of Northwest A&F University's 'Eucommia Corps'
  • Has long provided technical support for the comprehensive development of Eucommia in Lueyang County, Shaanxi (China's largest Eucommia-growing county, with 600,000 mu)
  • Participated in publishing monographs on Eucommia secondary metabolites

Key Contributions

  • Since 2000, has used HPLC and other techniques to map the chemical-component 'resource atlas' of different Eucommia parts, identifying leaves as a treasure house of chlorogenic acid and flavonoids and bark as the preferred source of Eucommia rubber and glycosides
  • First isolated nor-triterpene constituents with anti-neuroinflammatory activity from Eucommia leaves
  • As a major completer of 'Breeding of the Qinzhong 1-4 improved Eucommia varieties and in-depth development and utilization of secondary metabolites', won the 2017 Shaanxi Provincial Science and Technology Award (First Prize)
  • His findings provide a scientific basis for developing Eucommia-leaf functional foods and preventive drugs for neurodegenerative diseases such as Alzheimer's disease
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