出间武
Takeshi Deyama
人物简介
1980年代系统分离鉴定杜仲木脂素成分的日本学者
事迹
Takeshi Deyama任职于日本养命酒制造公司中央研究所（长野），是杜仲化学成分研究的国际先驱之一。1983年起他在《Chemical and Pharmaceutical Bulletin》发表六篇杜仲成分系列论文，系统分离鉴定了杜仲皮中的木脂素及其糖苷，为杜仲降压、抗氧化等功效研究奠定了化学基础。
他还率先研究杜仲木脂素在人体肠道菌群作用下的代谢转化，发现其终产物为具有雌激素样活性的肠内酯，揭示了杜仲“补肾”功效的可能现代机制，并在2007年首届国际杜仲研讨会上报告成果，与中国杜仲学界保持长期交流。
重要活动 / 事件
- 2007年在首届国际杜仲研讨会（International Symposium on Eucommia ulmoides）发表杜仲木脂素肠道代谢研究报告
- 与加拿大McMaster大学关超然等合作研究杜仲皮提取物经NO和EDHF介导的血管舒张机制（2004年）
代表贡献
- 1983-1987年在《Chemical and Pharmaceutical Bulletin》连续发表“The constituents of Eucommia ulmoides OLIV. Ⅰ-Ⅵ”系列论文
- 首次分离(+)-medioresinol二葡萄糖苷、eucommin A等多个杜仲新木脂素苷并确定结构
- 发现杜仲木脂素苷对cAMP磷酸二酯酶的抑制作用（1988年）
- 2001年在Acta Pharmacologica Sinica发表杜仲与刺五加成分及药理综述，被引270余次
- 与服部征雄等合作阐明松脂醇二葡萄糖苷经人肠道菌群转化为肠内酯的代谢途径（2003年）
Profile
Japanese scholar who systematically isolated and identified Eucommia lignan constituents in the 1980s
Story
Takeshi Deyama worked at the Central Research Laboratories of Yomeishu Seizo Co. (Nagano, Japan) and is one of the international pioneers in chemical research on Eucommia constituents. Beginning in 1983, he published a six-part series on Eucommia constituents in Chemical and Pharmaceutical Bulletin, systematically isolating and identifying lignans and their glycosides from Eucommia bark and laying the chemical foundation for research on its antihypertensive and antioxidant effects.
He was also the first to study the metabolic transformation of Eucommia lignans by human intestinal flora, finding that their end product is enterolactone, which has estrogen-like activity—revealing a possible modern mechanism for Eucommia's 'kidney-tonifying' efficacy. He reported these results at the first International Symposium on Eucommia ulmoides in 2007 and maintained long-term exchanges with the Chinese Eucommia research community.
Milestones
- Presented research on the intestinal metabolism of Eucommia lignans at the first International Symposium on Eucommia ulmoides in 2007
- Collaborated with Guan Chaoran and colleagues at McMaster University, Canada, on the vasodilatory mechanism of Eucommia bark extract mediated by NO and EDHF (2004)
Key Contributions
- Published the six-part series 'The Constituents of Eucommia ulmoides OLIV. I–VI' in Chemical and Pharmaceutical Bulletin from 1983 to 1987
- First isolated several new Eucommia lignan glycosides, including (+)-medioresinol diglucoside and eucommin A, and determined their structures
- Discovered the inhibitory effect of Eucommia lignan glycosides on cAMP phosphodiesterase (1988)
- Published a review on the constituents and pharmacology of Eucommia and Eleutherococcus (Ciwujia) in Acta Pharmacologica Sinica in 2001, cited over 270 times
- In collaboration with Yukio Hattori and others, elucidated the metabolic pathway by which pinoresinol diglucoside is converted to enterolactone by human intestinal flora (2003)
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